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Inhibition of <i>FLT3i>: A Prototype for Molecular Targeted Therapy in Acute Myeloid Leukemia Review

Meira Yisraeli Salman, Jacob M. Rowe, Nir Weigert

Engineering 2021, Volume 7, Issue 10,   Pages 1354-1368 doi: 10.1016/j.eng.2021.05.020

Abstract: The efficacy of MRD has rapidly progressed in the past decade, from a specificity of 10−33(FLT3) inhibitors, which have impacted the prognostication and therapeutics of AML.This review selectively discusses the FLT3 inhibitors in detail, as a model for the other burgeoning

Keywords： AMLTargeted therapy     <i>FLT3i> inhibitors     Midostaurin     Gilteritinib     Quizartinib     Sorafenib    

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Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 433-444 doi: 10.1007/s11705-014-1454-6

Abstract: Previous studies have found that three peptide inhibitors (i.e., KLVFF, VVIA, and LPFFD) can inhibitHowever, atomic details of binding modes and binding affinities between these peptide inhibitors andAll inhibitors exhibit varied binding affinity to A , in which KLVFF has the highest binding affinityMM/PBSA analysis further revealed that different peptide inhibitors have different modes of interactionSpecific residue-based interactions between inhibitors and A were determined and compared for illustrating

Keywords： Alzheimer’s disease     amyloid <i>βi>-protein     peptide inhibitors     protein-protein interaction     molecular    

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Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 808-814 doi: 10.1007/s11684-021-0878-x

Abstract: Chinese families with EB, and eight variants including a novel nonsense variant (c.47G>A, p.W16*) in <i>LAMA3i>, a known recurrent variant (c.74C>T, p.P25L) in <i>KRT5i>, 2 novel (c.2531T>A, p.V844E; cCOL7A1 i>were detected.Notably, this study identified a nonsense variant in <i>LAMA3i> that causes EB within the Chinese populationand revealed that this variant resulted in a reduction in <i>LAMA3i> mRNA and protein expression levels

Keywords： epidermolysis bullosa     <i>LAMA3i>     <i>COL7A1i>     <i>KRT5i>     Chinese families    

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Development of an H reduction and moderate oxidation method for 3,5-dimethylpyridine hydrogenation in

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 12,   Pages 1807-1817 doi: 10.1007/s11705-022-2243-2

Abstract: The Ru/C catalyst prepared by impregnation method was used for hydrogenation of 3,5-dimethylpyridinei> reduced Ru/C-n catalyst was higher than that of the <i>in-situi> reduced Ru/C-y catalyst.the highest 3,5-dimethylpyridine conversion was obtained for the Ru/C-i1 catalyst prepared by <i>in-situof the <i>in-situi> H2 reduction and moderate oxidized Ru/C-i2 catalyst, the interactionbetween RuO<i>xi> species and the support changed, and the hard-to-reduce RuO<i>x<

Keywords： Ru/C catalyst     <i>in-situi> H2 reduction and moderate oxidation     <i>in-situi> reduction     non-<i>in-situi> reduction     hydrogenation of 3     5-dimethylpyridine    

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Development of lunar regolith-based composite for - 3D printing via high-pressure extrusion system

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 2, doi: 10.1007/s11465-022-0745-8

Abstract: Thus, intensive research works have been conducted to develop types of 3D printing approach to adaptto the extreme environment and utilize the lunar regolith for <i>ini>-<i>situi> construction.However, the <i>ini>-<i>situi> 3D printing using raw lunar regolith consumes extremely high energyini>-<i>situi> resources of lunar regolith.ini>-<i>situi> manufacturing.

Keywords： <i>ini>-<i>situi> resource utilization     melt extrusion molding     lunar regolith-based composites    

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<i>NES1i>/<i>KLK10i> and <i>hNISi> gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 646-657 doi: 10.1007/s11684-018-0643-y

Abstract: , we supposed to have an “enhanced firepower” effect by combining overexpressed gene therapy and IResults of and tumor proliferation experiments and F-fluorothymidine ( F-FLT) micro-positron emissiontomography/computed tomography (micro-PET/CT) imaging showed that the combined gene therapy and Ithat via inhibition of expression, overexpressed might enhance the effect of radiation therapy of Iuptake in overexpressed PC3 cells.

Keywords： androgen-independent prostate cancer     normal epithelial cell-specific 1/kallikrein 10     sodium/iodide symporter     radiation therapy     proliferation    

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Evaluation of H2 on the Evolution Mechanism of NO<i>xi> Storage and Reductionover Pt–Ba–Ce/γ-Al2O3 Catalysts Article

Pan Wang, Jing Yi, Chuan Sun, Peng Luo, Lili Lei

Engineering 2019, Volume 5, Issue 3,   Pages 568-575 doi: 10.1016/j.eng.2019.02.005

Abstract:

In this investigation, Pt–Ba–Ce/γ-Al2O3 catalysts were preparedThe physical and chemical properties of the Pt–Ba–Ce/γ-Al2O3sub>, whose peaks were observed in X-ray diffraction (XRD) spectra, dispersed well on the γ-Al2O3,as shown by transmission electron microscope (TEM), and that the difference between Ce3+sub> storage efficiency and conversion were increased when the time of H2 exposure (i.e

Keywords： Pt–Ba–Ce/γ-Al2O3 catalysts     Physicochemical properties     NO<i>xi> storageand reduction     NO<i>xi> emission     H2 reductant    

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hybrid nanoflower through protein-inorganic self-assembly, and its application in glycyrrhetinic acid 3-

Tian Jiang, Yuhui Hou, Tengjiang Zhang, Xudong Feng, Chun Li

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 3,   Pages 554-562 doi: 10.1007/s11705-019-1834-z

Abstract: Glycyrrhetinic acid 3- -mono- -D-glucuronide (GAMG), an important pharmaceutical intermediate and functionalUsing site-directed mutagenesis, we previously obtained a variant of -glucuronidase from Li-3 (PGUS1

Keywords： <i>βi>-glucuronidase     enzyme-inorganic hybrid nanoflower     biotransformation     glycyrrhizin     glycyrrtinicacid 3-<i>Oi>-mono-<i>βi>-D-glucuronide    

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Protective efficacy of vaccination with NcMIC3 and NcMIC8 against

Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2,   Pages 188-196 doi: 10.15302/J-FASE-2019253

Abstract: Several studies have indicated that MIC3 and MIC8 are important adhesion factors and potential vaccineIn this study, we evaluated the protective efficacy of recombinant proteins and DNA vaccines of NcMIC3BALB/c mice were immunized with rNcMIC3, rNcMIC8, pcDNA3.1-NcMIC3 and pcDNA3.1-NcMIC8 respectively, andIn addition, mice immunized with rNcMIC3 and rNcMIC8 a had lower parasite burden in brain tissue comparedThese results demonstrate that rNcMIC3 and rNcMIC8 could induce humoral and Th2-type immune response,

Keywords： NcMIC3     NcMIC8     <i>Neospora caninumi>     vaccination    

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CeO doping boosted low-temperature NH-SCR activity of FeTiO catalyst: A microstructure analysis and reaction mechanistic study

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 5, doi: 10.1007/s11783-022-1539-2

Abstract: List>

• CeO2 doping significantly improved low-temperature NH3-SCR activity on FeTiO<i>xi>.

Keywords： NH3-SCR     CeO2 doping     Low-temperature NO<i>xi> removal     Improved redoxproperty     <i>In situi> XAFS analysis    

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Identification of an E3 ligase-encoding gene

Yanfei Zhang, Xinchun Zhao, Yongchun Zhou, Min Wang, Guangbiao Zhou

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 318-326 doi: 10.1007/s11684-019-0708-6

Abstract: We found that silencing of one of the candidates, that encodes an E3 ubiquitin ligase essential for

Keywords： <i>RFWD3i>     NSCLC     prognosis     tobacco smoke    

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Recent advances in special morphologic photocatalysts for NO removal

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 11, doi: 10.1007/s11783-022-1573-0

Abstract: List>

● Systematic information of recent progress in photocatalytic NO <i>x i> removal is provided.

Keywords： NO<i>xi> removal     Photocatalyst     Graphene     C3N4     Bi-based compounds    

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Superior performance in visible-light-driven hydrogen evolution reaction of three-dimensionally ordered macroporous SrTiO decorated with ZnCdS

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 6,   Pages 1561-1571 doi: 10.1007/s11705-021-2089-z

Abstract: In this study, we demonstrate the fabrication of three-dimensionally ordered macroporous SrTiO3 decorated with Zn<i>xi>Cd1−<i>xi>S nanoparticles for hydrogen

Keywords： three-dimensionally ordered macroporous SrTiO3     Zn<i>xi>Cd1–<i>xi>S     visible light     hydrogen production     promotion mechanism    

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FOXP3 and Its Cofactors as Targets of Immunotherapies Review

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Engineering 2019, Volume 5, Issue 1,   Pages 115-121 doi: 10.1016/j.eng.2019.01.001

Abstract:

Forkhead box P3 (FOXP3) is a "master regulator" of regulatory T cells (Tregs), which areAs a consequence, the PTMs change the stability of FOXP3 and its capability to regulate gene expressionAlthough FOXP3 per se is not an ideal drug target, deacetylases, acetyltransferases, kinases, and other enzymes that regulate the PTMs of FOXP3 are potential targets to modulate FOXP3 and TregFOXP3" side effects must be considered when inhibitors to these enzymes are used.

Keywords： Treg     Forkhead box P3 (FOXP3)     Post-translational modification     Autoimmune     Cancer    

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Identification of variants associated with sporadic thoracic aortic dissection: a case--control study

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 438-447 doi: 10.1007/s11684-020-0826-1

Abstract: We found that <i>COL3A1i> was significantly relevant to STAD (<i>Pi> = 7.35 × 10−6) after10 000 times permutation test (<i>Pi> = 2.49 × 10−3)., replicated our results (<i>Pi> = 0.021).Further bioinformatics analysis showed that <i>COL3A1i> was highly expressed in dissected aortic tissuesCOL3A1i> could increase the risk of STAD through the ECM pathway.

Keywords： sporadic thoracic aortic dissection     exome sequencing     gene <i>COL3A1i>     case–control study     extracellular    

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Title Author Date Type Operation

Inhibition of <i>FLT3i>: A Prototype for Molecular Targeted Therapy in Acute Myeloid Leukemia

Meira Yisraeli Salman, Jacob M. Rowe, Nir Weigert

Journal Article

Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Journal Article

Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in

Journal Article

Development of an H reduction and moderate oxidation method for 3,5-dimethylpyridine hydrogenation in

Journal Article

Development of lunar regolith-based composite for - 3D printing via high-pressure extrusion system

Journal Article

<i>NES1i>/<i>KLK10i> and <i>hNISi> gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Journal Article

Evaluation of H2 on the Evolution Mechanism of NO<i>xi> Storage and Reductionover Pt–Ba–Ce/γ-Al2O3 Catalysts

Pan Wang, Jing Yi, Chuan Sun, Peng Luo, Lili Lei

Journal Article

hybrid nanoflower through protein-inorganic self-assembly, and its application in glycyrrhetinic acid 3-

Tian Jiang, Yuhui Hou, Tengjiang Zhang, Xudong Feng, Chun Li

Journal Article

Protective efficacy of vaccination with NcMIC3 and NcMIC8 against

Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU

Journal Article

CeO doping boosted low-temperature NH-SCR activity of FeTiO catalyst: A microstructure analysis and reaction mechanistic study

Journal Article

Identification of an E3 ligase-encoding gene

Yanfei Zhang, Xinchun Zhao, Yongchun Zhou, Min Wang, Guangbiao Zhou

Journal Article

Recent advances in special morphologic photocatalysts for NO removal

Journal Article

Superior performance in visible-light-driven hydrogen evolution reaction of three-dimensionally ordered macroporous SrTiO decorated with ZnCdS

Journal Article

FOXP3 and Its Cofactors as Targets of Immunotherapies

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Journal Article

Identification of variants associated with sporadic thoracic aortic dissection: a case--control study

Journal Article